Prof. Dr. med. Prof. h.c. (VRC) Helmut K. Seitz, MD, AGAF
Distinguished Professor for Internal Medicine, Gastroenterology and Alcohol Research (Analogue Chair), University of Heidelberg, Germany
Address | Clinic: Ethianum Heidelberg, Voßstr. 6, 69115 Heidelberg, Germany Tel.: 0049 6221 8723-453 or -270 Fax: 0049 6221 8723-153 e-mail: helmut_karl.seitz@urz.uni-heidelberg.de |
Date of birth | May 27th 1950 |
Place of birth | Stuttgart, Baden-Wurttemberg |
Status: | married, one child |
School and University Education |
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1969 | Abitur (with distinction); Albert Schweitzer Gymnasium Leonberg, Baden Wurttemberg, Germany |
1969-70 | Stuttgart University, Chemistry |
1970-75 | Heidelberg University, Medicine |
9.12.1975 | Staatsexamen Medicine |
16.12.1975 | Dissertation (magna cum laude) Titel: Renal Excretion of Cyclic AMP in Secondary Hyperparathyroidism |
1976 | Tübingen University, Biochemistry |
Postdoc Training, Clinical Appointments and Professional Career |
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1976-77 | Medical Assistant, Departments of Surgery, Internal Medicine,and Pathology, University of Heidelberg, Germany |
1977-79 | Research Fellow (Deutsche Forschungsgemeinschaft) Alcohol Research and Treatment Centre, V.A. Medical Centre and Mount Sinai School of Medicine (City University of New York), New York, USA Direktor: Charles S. Lieber, M.D. |
12.06.1979 | ECFMG |
1979-85 | Assistant Physician, Department of Medicine (Gastroenterology), University of Heidelberg, Germany Director: Prof. Dr. B. Kommerell |
21.12.1983 | Consulting Physician for Internal Medicine |
26.8.1985 | Consulting Physician for Gastroenterology |
1986-91 | Assistant Medical Director Department of Medicine (Gastroenterology) (Director:Prof.Dr.B.Kommerell) und Medical Policlinic Director: Prof.Dr.W.Hunstein), University of Heidelberg |
1991-2020 | Direktor Department of Medicine (Gastroenterology), Salem Medical Centre, Heidelberg, Germany |
2000-2019 | Medical Director Salem Medical Centre, Heidelberg, Germany |
2001-2020 | Director Laboratory für Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre Heidelberg, Germany |
2007-2020 | Distinguished Professor for Internal Medicine, Gastroenterology and Alcohol Research, University of Heidelberg (analogue Chair) |
2010-2020 | Medical Director St Vincentius Hospital Heidelberg, and Chief Department of Internal Medicine, St Vincentius Hospital, Heidelberg, Germany |
Academic Appointments |
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1970-79 | Research Fellow (Deutsche Forschungsgemeinschaft), Alcohol Research and Treatment Centre, V.A. Medical Centre, Bronx, New York und Mount Sinai Medical Centre, New York, USA (Prof.Dr.Charles S.Lieber) |
19.7.1984 | Habilitation Internal Medicine (Experimental Studies on the cocarcinogenic effects of ethanol) |
14.2.1985 | Venia legend |
19.4.1985 | Inaugural (Pathogenesis of colorectal cancer) |
1986 | Northwick Park Hospital, MRC, London, Great Britain (Gerhard Katsch Fellowship of the German Society of Gastroenterology) |
1986 | USDA, Human Nutrition Research Centre. On Aging, Tufts University Boston, MA, USA (Gerhard Katsch Fellowship of the German Society of Gastroenterology) |
1991 | USDA, Human Nutrition Research Centre On Aging, Tufts University, Boston, MA, USA (Asche Fellowship of the German Association of Gastroenterology) |
27.9.1991 | Full Professor of Medicine, University of Heidelberg |
16.2.2004 | Honorary Professor Tongji Medical College, Huazhong Universität Wuhan, People’s Republic of China |
17.7.2007 | Distinguished Professor of Internal Medicine, Gastroenterology and Alcohol Research (analogue Chair), University of Heidelberg, Germany |
2008 | Fellow of the American Gastroenterological Association |
Grants |
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1977-79 | Postdoc Research Grant, Deutsche Forschungsgemeinschaft. Research Fellow, Alcohol Research and Treatment Centre, Bronx, New York, USA |
1981 | DAAD Grant: St. Marks Hospital, London |
1981-83 | Deutsche Forschungsgemeinschaft. Grant (Se 333/1-4) Alcohol and Gastrointestinal Tract |
1984-85 | Deutsche Forschungsgemeinschaft Grant (Se 333/6-1) Alcohol and rectal cancer: Bile Acids and colorectal cancer |
1986-88 | Deutsche Forschungsgemeinschaft Grant (Se 333/6-2) Colorectal carcinogenesis: Alcohol and cell regeneration |
1986 | Gerhard Katsch Studienstiftung (1.1.-30.4.1986)
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1990 | Asche Research Grant (Department of Gastroenterology and Nutrition, Nutrition Research Centre, Tufts University, Boston, USA) Title: Alcoholdehydrogenase in the human stomach |
1993-1996 | Biomed and Health Research (Biomed 1) Grant of the European Community: Genetics and Biochemical Determinants of Alcohol Toxicity and Addiction.Together with
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1994-99 | British-German Academic Research Collaboration (ARC). (Prof.Timothy Peters) Dept. of Clinical Biochemistry, Kings College, London/UK. |
1999-2000 | Scientific Research Promotionprogram, Medical Faculty, University of Heidelberg (Alcohol induced pancreatic toxicity) Project 121/1999. In Colaboration with the Department of Surgery, University Heidelberg |
2007-12 | Research Grant Dietmar Hopp Foundation: Alcohol and Cancer (€ 517.000) |
2012-15 | Continuation of the Grant Dietmar Hopp Foundation: Alcohol and Cancer (€ 198.000) |
2009-14 | Research Grant Manfred Lautenschläger Foundation: Pathophysiological mechanisms of alcoholic liver disease (€ 250.000) |
2010-13 | Interdisciplinary Research Program (National Cancer Centre Heidelberg): DNA methylation as a biomarker for molecular diagnostic in human colon cancer (€ 100.000). Cooperation with PD Dr. H Linhart |
2010-14 | Research Grant Manfred Lautenschläger Foundation: Alcohol, hepatocellular damage and cancer (€ 237.000) Cooperation with Prof.Dr.S Mueller |
2011-16 | NIAAA Grant (GWAS on Alcohol and Liver Cirrhosis). Global Cooperative study (PI: Timothy Morgan, USA) ($ 2.600.000) Together with
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since 2014 | NIAAA Grant (Alcohol and Colorectal Cancer). (PI Vasilis Vasiliou, Yale University, New Haven, USA) |
Clinical Studies |
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1994-96 | 1994.1996 Sensitivity and Specificity of Ki-ras PCR in pancreatic cancer Cooperation with Dept. Hematology, University Homburg/Saar |
1995 | 1995 Effect of essential phospholipids and a-interferon on the progression of hepatitis C. In cooperation with Nattermann Company Köln |
1994-98 | Effect of Silymarin on mortality in alcoholic liver cirrhosis. Placebo controlled double blind multicentre trial (PI Seitz HK, Fleig W) |
2000-04 | Magnetspectroscopic studies in alcoholic hepatitis. Cooperationspartner German Cancer Centre (DKFZ) Heidelberg |
2006-10 | Conservative vs. surgical therapy in acute cholecystitis. Randomized Controlled Trial Cooperationspartner Department of Surgery University of Heidelberg |
since 2008 | International GWAS Study : Alcoholic cirrhosis oft the liver:(PI T. Morgan, USA) |
2010-13 | Epigenetics in colorectal cancer. Cooperationspartner: NCT und DKFZ Heidelberg |
since 2008 | Transient Elastography in alcoholic liver disease |
since 2014 | Effect of alcohol on carcinogenesis of colorectal cancer (PI Vasilis Vasiliou, Yale, USA) |
since 2015 | Effect of Chlormethiazol on alcoholic liver disease: randomized controlled Trial. (PI Seitz HK, Haefeli W) |
Awards and Honours |
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1984 | Walther und Christine Richtzenhain Preis German Cancer Reseasrch Centre (DKFZ), Heidelberg Title: Enhancement of 1,2-dimethyl-hydrazine induced rectal carcinogenesis following chronic ethanol consumption in the rat |
1985 | St. Gallen Research Award St.Gallen, Schweiz Title: Experimental animal studies on the cocarcinogenic effect of alcohol on the rectum |
1986 | Homburg Prize Regensburger Kollegium für ärztliche Fortbildung, Regensburg Title: Alcohol and Cocarcinogenesis |
1987 | Hans-Adolf Krebs Prize German Society for Nutrition (Deutsche Gesellschaft für Ernährung), München Title: Studies on the influence of age on the metabolism and the toxicity of alcohol taking into consideration vitamins A and E |
1990 | Asche Research Grant of the German Gastroenterologic Association Titel: Studies on alcohol dehydrogenase in the human gut: influence of age and chronic-atrophic gastritis on the first pass metabolism of ethanol in man |
1992 | Recognition of the scientific contribution to ALCOHOL AND CANCER on the cover page of the journal CANCER RESEARCH (52: 3831, 1992) |
1993 | Invitation and Participation 86th Nobel Symposium ‚Towards a molecular base of alcohol use and abuse‘, Karolinska-Institute, Stockholm, Schweden (19.-23. September 1993) |
1996 | CHARLES-Medal, Karls Universität Prague, Tschech Republic |
1997 | Recognition of the scientific contribution on the front page of the International Journal of Oncology (July issue 1997) |
2008 | Fellow of the American Gastroenterologic Association (AGA) |
2010 | Hiromasha Ishii Memorial Award of the International Society for Biomedical Research on Alcoholism, Paris, September 2010 |
2011 | Invited Lecture by the Japanes Society for Gastroenterology: A tribute to the late Professor Hiromasha Ishii, Fukuoka, Japan (6th International Symposium on ALPD and Cirrhosis: |
2013 | European Alcohol Research Award oft the European Society for Biomedical Research on Alcoholism (ESBRA) Warsaw, September 2013 |
2017 | Awarding of the silver medal of Charles University, Prague, Czech Republic |
State-of-the-Art Lectures |
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2003 | Plenary Lecture at the ESBRA Congress, Prague, Czech Republic on Alcohol and Cancer. 11.-14.September 2003 |
2004 | Alcoholic Liver Disease: New concepts in pathogenesis ESBRA Nordman Award Meeting, 2004 Alcohol and Cannabis from basic to clinical Research. Lisabon, Portugal 28./29. Mai 2004 |
2004 | Alcoholic Liver Disease: Alcohol or Genes? European Society of Parenteral and Enteral Nutrition (ESPEN) Lisabon, Portugal 10. September 2004 |
2006 | Alcohol and carcinogenesis State of the Art Lecture. VA Medical Center, Bronx, New York, USA, 25. Mai 2006 |
2007 | Molecular mechanisms of alcohol mediated carcinogenesis (state-of-the art lecture) European Society for Laboratory Medicine Prag, Czech Republic 16. September 2007 |
2008 | Molecular mechanisms of alcohol mediated carcinogenesis 14. ISBRA Congress, Washington DC 29.Juni 2008 |
2013 | Alcohol and Cancer, 14th ESBRA Congress, Warsaw, Poland 8.-11. September 2013 |
2014 | Invitation Annual Congress of the Guatemala Society for Gastroenterology, Antigua, Guatemala 24.-27. Juli 2014 |
2015 | Alcoholic liver diseases. Kaplan Centre, Rehovot, Israel, Januar 2015 |
2016 | Representative of the United European Gastroenterology in Suzou, VR China, New Developments in Gastroenterology, Suzou, September 2016 |
2017 | Alcohol and cancer. International Congress Gastroenterology, University of Padova, Italy, Januar 2017 |
2017 | Alcohol and cancer. Congress of the Italian Gastroenterologic Society, Rom, Oktober 2017 |
2018 | Alcoholic Liver Disease. Titisee Symposium, Februar 2018 |
Alcoholic Liver Disease. Romanian German Society for Gastroenterology, Brashov, Rumänien, April 2018 | |
2019 | The role of cytochrome P4502E1 in alcoholic liver disease and cancer. ESBRA Congress, Lille, France, September 2019 |
Visiting Professorships |
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1986-2005 | Nutrition and Oncology Lab., Human Nutrition Research Centre on Aging, Tufts University, Boston, USA (jährlich) |
1987 | Dept. Med. University of Illinois at Chicago, USA |
1988, 2004 | Tongji Medical College, Huazhong University, Wuhan, PR China |
since 1991 | Dept. of Preventive Medicine, University of Zurich, Switzerland (jährlich) |
1993 | Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona, Spain |
1994,2002 | Research Unit of Substance Abuse Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland |
1995 | Dept. Med. La Jolla University, Chicago, USA |
1995 | Laboratoire de Biochimie-Nutrition, Universite de Brest, France |
2000 | Arab University Beirut/Lebanon (2 Wochen Kurs) |
2006 | Alcohol Research and Treatment Centre, VA Medical Centre, Bronx, New York USA |
2013 | University of Tennessee Health Science Centre, Memphis, USA |
2014 | Member of the Doctoral Examination, Maastricht, Netherlands, January 2014 |
Panel and Faculty Memberships |
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1999 | Member of an international panel of the EC for the evaluation of Portuguese science |
2007 | Member of an International panel on Alcohol & Cancer, International Agency for Research and Cancer (IARC), Lyon, France (6.-13 February 2007) |
2009 | Mitglied einer Wissenschaftsdelegation des Landes Baden Württemberg in das Sultanat Brunei 14.-18.November 2009 |
2010 | Wien EASL |
2010 | Extramural Advisor for the NIAAA on Alcohol and Cancer (8/9 June 2010, Rockville, USA) |
2010 | Faculty Member of the United European Gastroenterology Week (UEGW) in Barcelona, Spain |
2010 | Mitglied einer Wissenschaftsdelegation des Landes Baden Württemberg nach Saudi Arabien 23.-28. April 2010 |
2010 | Charles Lieber Memorial Symposium, RSA San Antonio, Texas, USA Juni 2010 |
2011 | Member of a European Panel of the European Association for the Study of the Liver (EASL) for the Guidelines of Alcoholic Live Disease |
2011 | Charles Lieber Memorial Sympsoium, RSA, Atlanta, Georgia, USA, Juni 2011 |
2011 | Faculty Member of the United European Gastroenterology Week (UEGW) in Stockholm, Sweden |
2011 | EASL Berlin |
2012 | Faculty Member of the European Association for the Study of the Liver (Barcelona, Spain) |
2012 | Invitation as ad hoc extramural Advisor to the NIAAA for Alcoholic Hepatitis, Rockville, Maryland, USA (7/8. February 2012) |
2013 | Faculty Member of the European Association for the Study of the Liver (Amsterdam, The Netherlands, 24.-28. April 2013) |
2013 | Charles Lieber Memorial Symposium, RSA, Orlando, Florida, Juni 2013 |
2013 | Faculty Member of the United European Gastroenterology Week (UEGW) in Berlin, Germany, October 2013 |
2014 | Member of the Dissertation Board, Maastrich, The Netherlands (23. Januar 2014) |
2014 | Faculty Member of the European Association for the Study of the Liver (London, UK 9.-13. April 2014) |
2014 | Charles Lieber Memorial Symposium, RSA, Seattle, Washington, USA, Juni 2014 |
2014 | Leitlinien NAFLD, Deutsche Gesellschaft für Verdauungs und Stoffwechselerkrankungen |
2014 | Faculty Member of the United European Gastroenterology Week (UEGW), Wien Austria, October 2014 |
2015 | Faculty Member 3rd. Congress on Alcohol and Cancer, Heraklion, Kreta, Mai 2015 |
2015 | Charles Lieber Memorial Symposium, RSA, San Antonio, USA, Juni 2015 |
2015 | Faculty Member ESBRA Konfress Valencia, Spanien, September 2015 |
2015 | Faculty Member UEWG, Barcelona, Oktober 2015 |
2016 | ISBRA Kongress Berlin, BRD, September 2016 |
2016 | Charles Lieber Memorial Symposium, RSA, New Orkleans, USA, Juni 2016 |
2017 | The Gordon Conference: Alcohol-induced end organ diseases, Ventura, Kalifornien, USA, März 2017 |
2017 | Charles Lieber memorial Symposium, RSA, Denver, USA, Juni 2017 |
2018 | Charles Lieber Memorial Symposium, RSA, San Diego, USA, Juni 2018 |
2019 | Faculty Member 4th Congress on Alcohol and Cancer, Newport, USA, April 2019 |
2019 | Charles Lieber Memorial Symposium, Minneapolis, USA, Juni 2019 |
Chairs |
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1988 | Alcohol and Cancer. IV. Congress of the International Society for Biomedical Research on Alcoholism (ISBRA). Chairman and Organizer of the Workshop. Kyoto, Japan, Juni 1988 |
2000 | Alkohol und gastroenterologische Erkrankungen. Symposium Jahrestagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (Vorsitz H.K. Seitz, M. Singer). Hamburg, 15. September 2000 |
2001 | The role of Gastric Emptying in First Pass Metabolism of Ethanol. Symposium First Pass Metbolism of Ethanol (Vorsitz: Yin Taipeh, H.K. Seitz), 8th ESBRA Congress. Paris/Frankreich, 15.-18. September 2001. |
2002 | Labor, Klinik und Verlauf von NASH und ASH. Symposium NASH und ASH: Gemeinsamkeiten und Unterschiede (Vorsitz: Plauth/Seitz). Deutscher Internistenkongress. Wiesbaden, 9. April 2002 |
2002 | Gastrointestinal metabolism of ethanol and its possible role in carcinogenesis.Symposium on alcohol metabolism - role in toxicity and carcinogenesis (Vorsitz: T. Badger, H.K. Seitz, P. Yin). 12th ISBRA Congress. San Francisco/USA, 28. Juni -3. Juli 2002 |
2002 | Alkoholfolgekrankheiten in der Gastroenterologie. Arbeitssitzung (Vorsitz: P. Schuppan, H.K. Seitz). 57. Tagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten. Bonn, 20. September 2002 |
2004 | Alkohol und Krebs (Symposiumsvorsitz) Jahrestagung der deutschen Krebsgesellschaft Berlin, 27. Februar 2004 |
2004 | Alkohol und Retinoide. Workshop Alkohol (Vorsitz mit Prof. Singer). Jahrestagung Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten. Leipzig 1. September 2004 |
2004 | Alcoholic Liver Disease: From Pathophysiology to Therapy (Vorsitz mit Charles Lieber). International Society for Biomedical Research on Alcoholism. 12th World Congress on Biomedical Research. Heidelberg/ Mannheim 29. September - 2. Oktober 2004 |
2004 | Alcohol and the gastrointestinal tract. In: Alcohol related pathology from head to toe, a synopsis of alcohol-related pathology which also celebrates the work and retirement of Prof. Timothy J. Peters (Chair and organizer). ISBRA Satellite meeting 2004, Heidelberg 29. September 2004 |
2004 | ADH1C polymorphism and risk of cancer. In: From alcohol toxicity to treatment. Charles Lieber Alumni Meeting 2004 ISBRA Satellite Meeting 2004 (Chair and Organizer). Mannheim 2. Oktober 2004 |
2004 | Alkohol als Kokarzinogen im Gastrointestinaltrakt. Symposium Cofaktor Alkohol bei gastrointestinalen Erkrankungen (Vorsitz mit Prof. Schuppan) Jahrestagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen Leipzig 2. Oktober 2004 |
2004 | Cancer of the upper aerodigestive tract and the large intestine: possible mechanisms. NIH Conference, mechanisms of alcohol associated cancers Chair. 6/7 October 2004 Bethesda, Maryland, USA) |
2008 | Alcoholic Steatohepatitis: established and experimental therapy Chair together with C.P.Day Workshop, European Association for the Study of the Liver (EASL) Milano, Italy 24.-26.April 2008. |
2010 | Invitation for the 1st Charles Lieber Memorial Symposium during the RSA Congress in San Antonio, Texas, USA |
2010 | Paris ISBRA 11.-15. September 2010 |
2010 | Stuttgart DGVS 16. September 2010 |
2011 | Invitation for the 2nd Charles Lieber Memorial Symposium during the RSA Congress in Atlanta, Georgia, USA |
2011 | Wien ESBRA 3.-7. September 2011 |
2012 | Invitation 2012 ISBRA Satellite Symposium, Kyoto, Japan, 14. September 2012 |
2012 | Sapporo ISBRA |
2013 | Invitation for the 4th Charles Lieber Memorial Symposium during the RSA Congress in Orlando, Florida, USA, 22.-25.Juni 2013 |
2013 | Nürnberg DGVS |
2014 | Invitation for the 5th Charles Lieber Memorial Symposium during the RSA/ ISBRA Congress, Seattle,USA 21-25 June 2014 |
2017 | SALVE Symposium, EASL, Amsterdam, Alcoholic Liver Disease, April 2017 |
2017 | EASL/ AASLD Joint Symposium on Alcoholic Liver Disease, London, Oktober 2017 |
Congree Organization |
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1999 | Treatment of alcoholic liver Disease: New Strategies. International Titisee Meeting – Alcohol in Health and Disease.(Organisator) Titisee/Deutschland, 9.-12. December 1999 |
1999 | Jahrestagung der Deutsch-Chinesischen Gesellschaft für Medizin, Heidelberg, September 1999 |
2010 | Organizer, 1st Congress on Alcohol and Cancer (Nordman Award Congress), Heidelberg, Germany, September 2010 |
2013 | Co-Organizer, 2nd Congress on Alcohol and Cancer, Breckenridge, Colorado, USA, 12-15 May 2013 |
2015 | Co-Organizer, 3rd Congress on Alcohol and Cancer, Crete, Greece 29. May-3. June 2015 |
2019 | Co-Organizer, 4th Congress on Alcohol and Cancer, Newport, USA, April 2019 |
Board Memberships and Presidencies |
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1995-99 | Secretary General German Chinese Medical Association |
1999-2004 | President German Chinese Medical Association |
1996-2012 | German Society for Traffic Medicine |
since 1996 | Member of the Scietific Board Deutschen Hauptstelle für Suchtfragen |
since 2009 | Speaker of the Scietific Board Deutschen Hauptstelle für Suchtfragen |
2001-05 | Vice President of ESBRA (European Society for Biomedical Research on Alcoholism) |
2005-13 | President of ESBRA (European Society for Biomedical Research on Alcoholism) |
since 2010 | Member of the Board of the International Society for Biomedical Research on Alcoholism (ISBRA) |
Memberships |
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since 1978 | New York Academy of Sciences |
since 1980 | Deutsche Gesellschaft für Verdauungs- und Stoffwechselerkrankungen |
since 1980 | European Association for the Study of the Liver (EASL) |
since 1981 | Société Francaise de Récherches Biomédicales en Alcoologie |
1985-2004 | German-Chinese Society of Medicine |
since 1985 | German Association for the Study of the Liver (GASL) |
since 1989 | European Society for Biomedical Research on Alcoholism (ESBRA) |
since 1989 | International Society for Biomedical Research on Alcoholism (ISBRA) |
since 1989 | International Gastro-Surgical Club |
since 1990 | American Gastroenterological Association (AGA) |
since 1992 | American Association for Cancer Research |
Journals |
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Associate Editor |
Alcohol and Alcoholism Sucht |
Editorial Board | Journal of Hepatology (1998-2006) Addiction Biology (1994-2000) |
Reviewer | Journal of Clinical Oncology Life Science Gastroenterology Hepatology Digestion Digestion Disease & Sciences Zeitschrift Gastroenterologie Toxicology Alcoholism: Clinical Experimental Research Gut Journal of Gastroenterology and Hepatology American Journal of Clinical Nutrition |
Ad Hoc Reviewer Nutrition Requirement Program of the United States, Department of Agriculture (USDA), Washington DC, USA | |
NATO Research Grant Reviewer | |
Author and Co-author of more than 460 papers and 12 books |